#4588 EFFECT OF TRISODIUM CITRATE 30% VERSUS HEPARIN AS A CATHETER LOCK SOLUTION ON INFLAMMATORY RESPONSE AND DIALYSIS ADEQUACY IN HEMODIALYSIS PATIENTS

Abstract Background and Aims In hemodialysis (HD) patients, the majority of bloodstream infections are caused by infection vascular access catheters. Commonly, Central venous catheters (CVCs) only option when HD is needed for patients without definitive access. However, in addition to infection, CVCs associated with other complications, such as thrombosis, dysfunction, leading higher mortality expenditures. Egypt, recent data show that 6.6% use a access, which short term represent 59.6% 40.4% long-term Many catheter-locking solutions could contribute reduction catheter-related especially infections. Aim; assess possible effect using Trisodium citrate 30% (TSC 30%) comparison unfractionated heparin, lock solution catheters, on inflammatory status, incidence catheter related Bacteremia (CRB) dialysis adequacy patients. Method This was randomized controlled clinical trial, conducted 70 prevalent regular recruited from unit Nasser Institute Hospital Cairo government at time insertion. Patients were divided into two groups: Citrate Group; 35 received trisodium after session, Heparin heparin (5000i.u) session. Both groups followed up 3 months period monitored signs CRB. Also, Urea ratio (URR) measured monthly. Highly sensitive CRP baseline start solutions. Blood cultures withdrawn who developed Results our study, bacteremia episodes significantly lower group compared group. Only 2 (5.7%) had CRB, whereas group, 8 (22.9%) CRB (P = 0.04) (Fig. 1). Bacteremia-free longer The mean free 10.97 ± 2.36 weeks, while it 9.43 3.91 weeks 0.032) 2). At base line, there no significant difference between both regarding hsCRP 0.596) WBCs 0.528). While TSC solution, regards levels 0.030) 3) 0.036), markers showed There studied thrombosis events. performance, assessed URR, 0.005) 0.108) 4). Conclusion we may conclude that, standard lock. its better performance adequacy. We therefore believe be potential alternative